Virginia Castilla Llorente
Chief Scientific Officer Cambridge Medixine Ltd
Virginia Castilla Llorente is Chief Scientific Officer at CamMed Therapeutics and a biotechnology leader with deep expertise in RNA biology and therapeutic platform development. She has held senior roles at Evox Therapeutics and SymphoRNA, advancing engineered extracellular vesicle and RNA delivery technologies. Virginia completed her PhD at the Severo Ochoa Molecular Biology Centre and conducted postdoctoral research at MSKCC, the Francis Crick Institute and UCL, focusing on microRNA, mRNA biology and gene regulation.
Seminars
- Leverage AI-driven discovery to identify novel eukaryotic RNA replicases and engineer a 1.8 kb non-viral self-amplifying system
- Demonstrate biochemical validation and cell data confirming functional RNA amplification
- Translate platform innovation toward therapeutic application through early protein replacement programs in MPSIIIA/B
Repeat-dose RNA therapeutics require careful engineering to reduce innate activation, expand the therapeutic window and support multi-dose regimens. This workshop provides a clear framework for understanding immunogenicity drivers, designing for tolerability and aligning dosing strategies with long-term clinical needs.
This workshop will gather experts to discuss:
- Reduce reactogenicity and strengthen safety margins by pinpointing innate immune activation pathways and integrating immunology, delivery, and regulatory considerations early in development
- Strategies to improve the potency of saRNA to drive lowered dosing and maximize the therapeutic window
- Differentiate the role of RNA design versus formulation and delivery in maximizing potency, durability, and dose efficiency
- Enable multi-cycle regimens by structuring redose-ready delivery and dosing strategies across diverse tissues and indications
This workshop is for:
Teams developing therapeutic RNA programs who need to overcome dose ceilings and enable safe, reliable redosing in autoimmune, oncology, neuromuscular or CNS applications
