Unlocking Trans-Amplifying RNA to Deliver Self-Amplifying Potency with Improved Manufacturability & Dosing Control • Achieve robust levels of protein expression without over
- Achieve robust levels of protein expression without oversized RNA constructs by separating replicase and payload RNAs to improve delivery efficiency, formulation flexibility, and translation across species
- Increased drug substance flexibility to reduce CMC, scale-up, and regulatory risk versus traditional saRNA by simplifying RNA length, improving batch consistency, and enabling more predictable manufacturing
- Expand therapeutic applicability beyond vaccines by using trans-amplifying RNA to enable tunable expression, lower dosing, and modular payload design for protein replacement and in vivo biologic delivery