circVec: A Circular RNA Vector–Driven Expression System for NextGeneration Cell and Gene Therapy
- circVec, a novel gene expression platform developed by Circio, utilizes the high intra-cellular stability of circular RNA (up to 75 times longer half-life than mRNA) to achieve enhanced protein expression from viral and non-viral DNA vectors
- The low decay rate of circular RNA leads to high accumulation over time, particularly in specific tissues, such as heart, spleen, and eye, which enables safer and/or more effective gene and cell therapy in these areas
- Low accumulation of circRNA in hepatic tissue and overall lower stimulation of the UPR pathway compared to mRNA-based vectors suggest reduced tox and cellular stress upon systemic injection of circVec-based vectors