What to Expect as RNA Comes Full Circle in 2026?
The 5th Circular & Self-Amplifying RNA Therapeutics Summit is designed for teams actively navigating the transition of circular and self-amplifying RNA from emerging modality to clinical reality.
As excitement gives way to execution, the field now faces a new set of challenges, including enabling durable expression, supporting redosing, aligning RNA design with delivery architecture, and building IND-ready CMC and regulatory strategies.
This highly-focused summit delivers three days of technical depth, strategic clarity, and peer-to-peer discussion, bringing together innovators from CirCode Biomed, Strand Therapeutics, Sail Biomedicines, Replicate Bioscience, HDT Bio, Chimeron Bio, Altamira Therapeutics, CSL, and leading academic institutions. The agenda prioritizes real-world lessons, first-in-human data, and platform-level decision-making across discovery, translation, and development.
Attendees can expect:
• Clinical and translational data validating circRNA and saRNA durability and safety
• Deep technical sessions on delivery beyond LNPs, immunogenicity engineering, and redosing strategies
• Practical guidance on CMC readiness, IP positioning, and regulatory alignment
• Workshops designed to reduce IND risk and accelerate development timelines
Built for discovery scientists, platform leaders, translational teams, CMC and regulatory experts, and biotech decision-makers, this summit offers the insight and connections required to move next-generation RNA therapeutics forward with confidence.
Unmissable Event Highlights
Validating Circular & Self-Amplifying RNA in the Clinic
Examine first-in-human and translational data demonstrating durable expression, tissue selectivity, and clinically relevant dosing across emerging RNA programs.
Engineering Durable, Low-Dose RNA Expression
Learn how next-generation RNA architectures and modifications are extending expression from weeks to months while reducing dose and immune burden.
Unlocking Extrahepatic Delivery Beyond LNPs
Discover novel delivery strategies are enabling redosing and access to previously unreachable tissues using peptide-based and non-LNP systems.
Enabling In Vivo CAR-T and Immune Reprogramming with Circular and Self-Amplifying RNA
Discover how next-generation RNA modalities are replacing complex ex vivo cell therapies with scalable, injectable in vivo CAR-T solutions.
- 60+ RNA Innovators from leading biotech, pharma & academia
- 16+ Expert Speakers driving circRNA & saRNA clinical translation
- 15+ Data-Led Case Studies spanning discovery to IND execution
- 8+ Hours of Structured Networking with senior RNA decision-makers
- 2 Deep-Dive Workshops tackling immunogenicity, dosing & CMC strategy
Attending Companies Include
Explore the Agenda
Dive into data-driven sessions tackling durability, delivery, immunogenicity, and IND readiness for circular and self-amplifying RNA.
Partner With Us
Connect with RNA developers actively seeking solutions across discovery, delivery, manufacturing, and regulatory strategy.
Join Biopharma Experts
Network with the scientists and leaders shaping the next wave of RNA medicines beyond linear mRNA.