Anna Blakney
Assistant Professor University of British Columbia
Seminars
Tuesday 26th May 2026
Engineering Immunogenicity & Dosing Strategies to Enable Redosing & Expand Therapeutic Reach
Repeat-dose RNA therapeutics require careful engineering to reduce innate activation, expand the therapeutic window and support multi-dose regimens. This workshop provides a clear framework for understanding immunogenicity drivers, designing for tolerability and aligning dosing strategies with long-term clinical needs.
This workshop will gather experts to discuss:
- Reduce reactogenicity and strengthen safety margins by pinpointing innate immune activation pathways and integrating immunology, delivery, and regulatory considerations early in development
- Strategies to improve the potency of saRNA to drive lowered dosing and maximize the therapeutic window
- Differentiate the role of RNA design versus formulation and delivery in maximizing potency, durability, and dose efficiency
- Enable multi-cycle regimens by structuring redose-ready delivery and dosing strategies across diverse tissues and indications
This workshop is for:
Teams developing therapeutic RNA programs who need to overcome dose ceilings and enable safe, reliable redosing in autoimmune, oncology, neuromuscular or CNS applications
Wednesday 27th May 2026
Achieving Long-Duration Hepatic Expression with Optimized Self-Amplifying RNA to Transform the Future of Protein Replacement Therapies
3:15 pm
- Deliver 30-day liver expression after IV administration for the first time by integrating RNA engineering with advanced formulation strategies to overcome historic expression failure in hepatic tissues
- Unlock therapeutic feasibility for saRNA-based protein replacement by matching the durability of viral systems without relying on genome integration or high-dose repeat administration
- Reveal mechanistic and translational insights from optimizing saRNA constructs to guide the next wave of durable, redose-ready therapeutic applications beyond vaccines
