Second Generation Self-Replicating RNA & its Utility for Vaccine Applications & Beyond
Time: 3:00 pm
day: Conference Day Two
Details:
• Replicate has designed 2nd generation self-replicating RNAs by vectorizing new members of the alphavirus family, along with non-coding region optimization
• Vaccines from 2nd generation srRNAs are effective at ultra-low doses
• Clinical testing of a 2nd generation srRNA vaccine resulted in strong immunogenicity in a naive population without SAEs or DLTs
