Repeat-dose RNA therapeutics require careful engineering to reduce innate activation, expand the therapeutic window and support multi-dose regimens. This workshop provides a clear framework for understanding immunogenicity drivers, designing for tolerability and aligning dosing strategies with long-term clinical needs.

This workshop will gather experts to discuss: 

• Reduce reactogenicity and strengthen safety margins by pinpointing innate immune activation pathways and integrating immunology, delivery, and regulatory considerations early in development
• Strategies to improve the potency of saRNA to drive lowered dosing and maximize the therapeutic window
• Differentiate the role of RNA design versus formulation and delivery in maximizing potency, durability, and dose efficiency
• Enable multi-cycle regimens by structuring redose-ready delivery and dosing strategies across diverse tissues and indications

This workshop is for: 

Teams developing therapeutic RNA programs who need to overcome dose ceilings and enable safe, reliable redosing in autoimmune, oncology, neuromuscular or CNS applications