Aligning Self-Amplifying RNA & High-Efficiency Delivery Vectors to Enable Potent, Localized In Vivo CAR-T Activity
- Increase intratumoral protein levels by pairing self-amplifying RNA with a highly efficient non-LNP delivery system that drives superior cellular uptake and minimizes systemic leakage
- Unlock complex, multi-gene therapeutic designs by combining amplification capacity with a vector capable of carrying larger and multiple payloads for deeper IO impact
- Enhance tumor-selective activity and safety by generating high local expression without blood-borne exposure, enabling in vivo CAR-T mechanisms previously unattainable with LNP or linear mRNA