Advancing Peptide-Based circRNA Delivery to Enable Extrahepatic, Inflammation-Tolerant RNA Therapeutics
- Demonstrate delivery compatibility and performance of circular RNA by using xPhore™ peptide-based nanoparticles to achieve efficient cellular uptake and expression across multiple cell types
- Differentiate circRNA and linear mRNA applications through head-to-head delivery comparisons, highlighting how identical delivery architectures reveal modality-specific expression profiles and use-case fit
- Expand RNA therapeutic reach beyond LNP-dominated paradigms by enabling extrahepatic and inflammation-tolerant delivery suitable for tissues poorly served by conventional lipid-based systems