8:00 am Check-In & Light Breakfast
8:50 am Chair’s Opening Remarks
Optimizing Self-Amplifying RNA Construct Design to Achieve Greater Stability & Reduced Cytotoxicity for More Durable Therapies
9:00 am Engineering Sa-mRNA Structure to Improve Vaccine Product Stability & Functionality
Synopsis
• We can modulate sa-mRNA structure properties through sequence design
• Stabilization of RNA structure leads to improved sa-mRNA stability in solution and in LNP
• Sa-mRNA stability and translation balance can be achieved through iterative design learning cycles
New Data
New Company
9:30 am Creating a Novel SaRNA Backbone to Improve Payload Expression & Cell Type Targeting
Synopsis
• Designing a saRNA backbone with reduced cytotoxicity to improve safety for saRNAbased therapeutics
• Uncovering a novel saRNA backbone which enhances payload expression by minimizing immunogenicity
• Achieving cell specific targeting and expression with this novel saRNA
10:00 am Morning Break & Speed Networking
Synopsis
This session is your opportunity to get face-to-face with many of the brightest minds working in the circular and self-amplifying RNA field, and establish meaningful business relationships to pursue for the rest of the conference
Leveraging AI & Analytical Methods to Improve RNA Design & Quality for More Potent Next Generation RNA Therapeutics
11:00 am Advancing Analytical Methods Enabling Circular RNA Pharmaceutical Preparedness
Synopsis
• Discuss strategies to develop new methods for circular RNA while leveraging platformed methods from linear mRNA where possible
• Review orthogonal analytical approaches for confirming identity of circular RNA and associated impurities
• Uncovering analytical methods for supporting quality control processes for circular RNA payloads
New Data
New Company
11:30 am Roundtable Discussion: Harnessing AI & Computational Modelling for Designing Circular & Self-Amplifying RNA Constructs with Improved Efficacy & Reduced Immunogenicity
Synopsis
• Navigating the potential of incorporating computational techniques in the discovery and development of RNA therapeutics
• Highlighting the use of AI and computational modelling into sequence design and immune response prediction for more efficacious therapeutics
• How to use AI to design RNA constructs which will translate well in vivo and create long lasting results?
12:15 pm Lunch & Networking
Navigating Delivery for Circular & Self-Amplifying RNAs to Achieve Specific Targeting Leading to Enhanced Potency
1:15 pm Developing Safe & Effective Delivery Technologies for Self-Amplifying RNA Vaccines & Therapeutics
Synopsis
• Discussing HDT bio’s LION™ delivery technology – a cationic nanocarrier that is structurally and functionally distinct from LNPs
• Leveraging LION for enabling saRNA encoded mAb therapies
• Thermostable formulations of saRNA vaccines
New Company
1:45 pm Deep-Dive Workshop: Accomplishing Improved Encapsulation & Targeting of RNA Therapeutics by Uncovering Innovative Delivery Strategies for More Potent & Effective Therapies
Synopsis
The largest bottleneck inhibiting the full potential of all RNA therapeutics is delivery. With self-amplifying and circular RNA payloads typically being larger than those of linear mRNA, this complicates their encapsulation. Therefore, during this workshop you will explore cutting-edge delivery strategies which enhance RNA stability, improve targeting precision, and optimize encapsulation for safe and specific tissue and cell targeting.
This session will deep dive into:
• Optimizing delivery strategies for efficient RNA encapsulation and specific tissue targeting
• Uncovering the promise of LNPs and AAVs for targeted delivery of circular and self-amplifying RNA therapeutics
• Delving into novel delivery vehicles for enhancing endosomal escape of RNA therapeutics
3:00 pm Afternoon Networking Break & Scientific Poster Session
Synopsis
Contribute to the conversation and share your cutting-edge research with your fellow RNA community to showcase your breakthrough discoveries to a vast audience of experts. Register your place to submit an abstract for review to showcase your poster*
*Please visit the website for the T&Cs for presenting a poster
Optimizing Manufacturing & Circularization Strategies for Large-Scale Production of Pure Therapies for the Patients in Need
3:30 pm Roundtable Discussion: Navigating Manufacturing Challenges for Circular & Self-Amplifying RNA to Improve Scalability, Purity & Yield for Regulatory Approval
Synopsis
• Improving manufacturing processes for enabling large scale production of circular and self-amplifying RNA therapeutics
• Delving into best practices in manufacturing, scaling up and purification of next generation RNA therapeutics
• Discussing learnings which can be taken from the standard linear mRNA production process
4:15 pm Improving Scalability & Quality of Circular RNAs for Vaccine Development
Synopsis
• Highlighting novel methods for accurate and reliable circularization of the mRNA
• Uncovering methods for improving CMC of circular RNAs to enable large scale and high-quality production
• Showcasing advances in circular RNA for vaccines in animal medicine
New Data
New Company
4:45 pm Untangling the Impacts of Process & Manufacturing on Self-Amplifying RNA Quality & Aligning with Safety & Immunogenicity in vitro and in vivo
Synopsis
• Delving into self-amplifying RNA critical quality attributes to inform high-quality manufacturing
• Understanding impact of formulation on host response to self-amplifying RNA for more potent and efficacious therapeutics and vaccines
• Determining how self-amplifying RNA quality will impact safety and immunogenicity in vitro and in vivo
New Data
New Company